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Mutation Information
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Mutation Site
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F97L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
C |
Literature Information
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PubMed PMID
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33879615
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Published Year
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2021 |
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Journal
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Proceedings of the National Academy of Sciences of the United States of America |
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Title
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A pocket-factor-triggered conformational switch in the hepatitis B virus capsid. |
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Author
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Lecoq L,Wang S,Dujardin M,Zimmermann P,Schuster L,Fogeron ML,Briday M,Schledorn M,Wiegand T,Cole L,Montserret R,Bressanelli S,Meier BH,Nassal M,Böckmann A |
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Evidence
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To pinpoint the structural origin of the two conformations, we compared capsids from further Cp types (SI Appendix, Table S2), namely, from sevenfold phosphorylated P7-Cp183 (SI Appendix, Fig. S2) (11), the partial phosphorylation mimic Cp183-EEE (11), the immature secretion variant Cp183-F97L, CTD-less Cp149, T = 3-dominated Cp140 capsids, genotype-G capsids (44), and cell-free synthesized CF-Cp183 (45).
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