HIV Mutation Detail Information

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Mutation Information

Mutation Site	G118R
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN
Relevant Drug	INSTIs
Country	Italy

Literature Information

PubMed PMID	30461149
Disease	HIV infection/AIDS
Published Year	2019
Journal	HIV medicine
Title	Prevalence and determinants of resistance mutations in HIV-1-infected patients exposed to integrase inhibitors in a large Italian cohort.
Author	Modica S,Rossetti B,Lombardi F,Lagi F,Maffeo M,D'Autilia R,Pecorari M,Vicenti I,Bruzzone B,Magnani G,Paolucci S,Francisci D,Penco G,Sacchini D,Zazzi M,De Luca A,Di Biagio A
Evidence	Decreased susceptibility to DTG, which coincided in our data set with the presence of Q148H/R/K plus at least one of G140A/C/S or E138A/K/T, was detected in 70 genotypes (15%) without differences between groups; R263K and G118R were not observed in any genotype (Fig. 1).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation