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Mutation Information
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Mutation Site
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G140S |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
IN |
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Genotype/Subtype
|
C |
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Relevant Drug
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INSTIs |
Literature Information
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PubMed PMID
|
32379830
|
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Published Year
|
2020 |
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Journal
|
PloS one |
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Title
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Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding. |
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Author
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Chitongo R,Obasa AE,Mikasi SG,Jacobs GB,Cloete R |
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Evidence
|
Three mutations known to be associated with Raltegravir, Elvitegravir and Dolutegravir resistance were selected;E92Q, G140S and Y143R, for molecular dynamics simulations.
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HIV Mutation Detail Information