|
Mutation Information
|
Mutation Site
|
G145R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Relevant Drug
|
lamivudine (LAM);ganciclovir (GCV) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
10320044
|
|
Disease
|
Liver cirrhosis
|
|
Published Year
|
1999 |
|
Journal
|
Antiviral research |
|
Title
|
Hepatitis B virus variants with lamivudine-related mutations in the DNA polymerase and the 'a' epitope of the surface antigen are sensitive to ganciclovir. |
|
Author
|
Oon CJ,Chen WN,Lim N,Koh S,Lim GK,Leong AL,Tan GS |
|
Evidence
|
Both the wild type HBV and lamivudine-related mutants with the Gly145-->Arg145 HBsAg mutation were suppressed following ganciclovir treatment, indicating a beneficial additive effect of both drugs against different forms of HBV mutants.
|
|
|
HBV Mutation Detail Information