|
Mutation Information
|
Mutation Site
|
G145R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
s.G145R+s.F134Y |
|
Genotype/Subtype
|
C |
Literature Information
|
PubMed PMID
|
10596008
|
|
Disease
|
HBV infection
|
|
Published Year
|
2000 |
|
Journal
|
Journal of medical virology |
|
Title
|
Effect of variation in the common "a" determinant on the antigenicity of hepatitis B surface antigen. |
|
Author
|
Seddigh-Tonekaboni S,Waters JA,Jeffers S,Gehrke R,Ofenloch B,Horsch A,Hess G,Thomas HC,Karayiannis P |
|
Evidence
|
The results suggest that amino acid substitution of T131I, K141E and G145R and insertion of 3 amino acids between residues 123 and 124 markedly affect the antigenic structure of HBsAg.
|
|
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HBV Mutation Detail Information