|
Mutation Information
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Mutation Site
|
G145R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Immune Escape
|
Y |
|
Relevant Drug
|
hepatitis B immunoglobulin (HBIG) |
Literature Information
|
PubMed PMID
|
11395201
|
|
Published Year
|
2001 |
|
Journal
|
Vaccine |
|
Title
|
Anti-HBs after hepatitis B immunization with plasma-derived and recombinant DNA-derived vaccines: binding to mutant HBsAg. |
|
Author
|
Heijtink RA,van Bergen P,van Roosmalen MH,Sünnen CM,Paulij WP,Schalm SW,Osterhaus AD |
|
Evidence
|
The G145R mutant of the small S-protein is a major escape mutant of hepatitis B virus observed in natural infection, after immunization and HBIG therapy.
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HBV Mutation Detail Information