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Mutation Information
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Mutation Site
|
G145R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
D |
|
Immune Escape
|
Y |
|
Country
|
Italy |
Literature Information
|
PubMed PMID
|
20130415
|
|
Disease
|
Occult HBV infection
|
|
Published Year
|
2010 |
|
Journal
|
Intervirology |
|
Title
|
Appearance of HbeAg in an occult persistent hepatitis B virus infection. |
|
Author
|
Paparella C,De Rosa F,Longo R,Cappiello G,Ursitti A,Rosa M,Morosetti M,Spanò A |
|
Evidence
|
A male patient with severe systemic diseases, positive for anti-HBc and anti-HBs and negative for all other HBV markers, including HBsAg, since at least 4 years, showed a positivity for HBeAg at a follow-up control in November 2008; HBV-DNA testing by real-time PCR evidenced very low levels of viremia (<40 IU/ml), direct sequencing of the surface antigen-coding and Pol/RT coding regions allowed the identification of genotype D, serotype adw2, one immune escape mutation (G145R) and no drug resistance mutations.
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HBV Mutation Detail Information