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Mutation Information
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Mutation Site
|
G145R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
C;D |
|
Immune Escape
|
Y |
|
Relevant Drug
|
tenofovir (TDF) |
Literature Information
|
PubMed PMID
|
26390290
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2015 |
|
Journal
|
PloS one |
|
Title
|
Detection of Hepatitis B Virus (HBV) Genomes and HBV Drug Resistant Variants by Deep Sequencing Analysis of HBV Genomes in Immune Cell Subsets of HBV Mono-Infected and/or Human Immunodeficiency Virus Type-1 (HIV-1) and HBV Co-Infected Individuals. |
|
Author
|
Lee Z,Nishikawa S,Gao S,Eksteen JB,Czub M,Gill MJ,Osiowy C,van der Meer F,van Marle G,Coffin CS |
|
Evidence
|
In the CD4+ and CD56+ subset of 2 HBV monoinfected cases on tenofovir therapy, mutations at residues associated with drug resistance and/or immune escape (i.e., G145R) were detected in a minor percentage of the population.
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HBV Mutation Detail Information