|
Mutation Information
|
Mutation Site
|
G145R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
B;C;D |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Indonesia;China;India;South Korea |
Literature Information
|
PubMed PMID
|
29713126
|
|
Published Year
|
2018 |
|
Journal
|
World journal of gastroenterology |
|
Title
|
Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression. |
|
Author
|
Choi YM,Lee SY,Kim BJ |
|
Evidence
|
Notably, these authors also found that RT mutations in the A-B interdomain could lead to simultaneous AA substitutions sI126A/N/S/, sG130N, sT131N/P, and sG145R of the overlapped ‘a’ determinant of HBsAg, including the most frequently described immune-escape mutation sG145R (1/192, 0.52%)
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HBV Mutation Detail Information