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Mutation Information
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Mutation Site
|
G163R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
raltegravir (RAL);etravirine(ETR);darunavir (DRV);ritonavir;enfuvirtide (T20);elvitegravir (EVG) |
|
Country
|
France |
Literature Information
|
PubMed PMID
|
20436677
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2010 |
|
Journal
|
PloS one |
|
Title
|
The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions. |
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Author
|
Reigadas S,Anies G,Masquelier B,Calmels C,Stuyver LJ,Parissi V,Fleury H,Andreola ML |
|
Evidence
|
Clonal analysis also showed that the T97A and G163R mutations could be present in association with Y143R but could also be selected in the absence of Y143R (in patients 2 and 3).
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HIV Mutation Detail Information