|
Mutation Information
|
Mutation Site
|
G1764A |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
C Promoter |
|
Combined Mutation
|
c promoter.G1764A+c promoter.A1762T |
|
Genotype/Subtype
|
A |
|
Country
|
Canada |
Literature Information
|
PubMed PMID
|
15985011
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2005 |
|
Journal
|
Journal of viral hepatitis |
|
Title
|
Response to long-term lamivudine treatment (up to 5 years) in patients with severe chronic hepatitis B, role of genotype and drug resistance. |
|
Author
|
Moskovitz DN,Osiowy C,Giles E,Tomlinson G,Heathcote EJ |
|
Evidence
|
Of the 10 genotype A patients with HBeAg negative hepatitis none possessed the precore (G to A at nucleotide 1896) mutation but all had the dual mutation within the core promoter (A1762T/G1764A).
|
|
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HBV Mutation Detail Information