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Mutation Information
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Mutation Site
|
G1764A |
|
Mutation Type
|
Nucleotide level |
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Gene/Protein/Region Type
|
BCP |
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Combined Mutation
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bcp.G1764A+bcp.A1762T |
|
Country
|
China |
Literature Information
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PubMed PMID
|
29628773
|
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Disease
|
Hepatocellular carcinoma
|
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Published Year
|
2018 |
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Journal
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Cancer management and research |
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Title
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The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study. |
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Author
|
Zhang Y,Huang J,Chen J,Yang K,Chen J,Xu L,Zhou Z,Chen M |
|
Evidence
|
Both A1762T/G1764A mutation and Pre S deletion related to worse overall survival (OS, p=0.040 and p<0.001, respectively) and disease-free survival (DFS, p=0.040 and p<0.001, respectively), G1899A mutation related to worse OS (p=0.030), A1762T/G1764A mutation correlated with tumor size (r=0.204, p=0.019), G1899A mutation correlated with vascular invasion (r=0.332, p<0.001), and Pre S deletion correlated with alpha-fetoprotein (AFP; r=0.254, p=0.003) positively.
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HBV Mutation Detail Information