|
Mutation Information
|
Mutation Site
|
G1896A |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
PreC |
|
Genotype/Subtype
|
E |
|
Country
|
South Africa |
Literature Information
|
PubMed PMID
|
29843851
|
|
Disease
|
HBV infection
|
|
Published Year
|
2018 |
|
Journal
|
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde |
|
Title
|
Fulminant hepatitis B virus (HBV) infection in an infant following mother-to-child transmission of an e-minus HBV mutant: Time to relook at HBV prophylaxis in South African infants. |
|
Author
|
Ogunbosi B,Smuts H,Eley B,Korsman S,De Lacy R,Hardie DR |
|
Evidence
|
Genetic analysis of virus from mother and infant showed that both had the G1896A mutation in the preC/C gene, which truncates hepatitis e antigen (HBeAg) during translation, causing an HBeAg-negative phenotype.
|
|
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HBV Mutation Detail Information