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Mutation Information
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Mutation Site
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G197I |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
IN |
Literature Information
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PubMed PMID
|
19014951
|
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Published Year
|
2009 |
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Journal
|
Journal of molecular biology |
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Title
|
Defining the DNA substrate binding sites on HIV-1 integrase. |
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Author
|
Dolan J,Chen A,Weber IT,Harrison RW,Leis J |
|
Evidence
|
When a HIV-1 G197I substitution, which caused a significant decrease in 3' processing, was combined into chimeras that alter LTR recognition, this resulted in purified enzymes that did not efficiently 3' process HIV-1 or ASV substrates.
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HIV Mutation Detail Information