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Mutation Information
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Mutation Site
|
G23A |
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Mutation Type
|
Nucleotide level |
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Gene/Protein/Region Type
|
PR |
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Nucleotide_Mutation
|
R8K |
Literature Information
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PubMed PMID
|
33649317
|
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Published Year
|
2021 |
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Journal
|
Nature communications |
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Title
|
Chemogenetic ON and OFF switches for RNA virus replication. |
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Author
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Heilmann E,Kimpel J,Hofer B,Rössler A,Blaas I,Egerer L,Nolden T,Urbiola C,Kräusslich HG,Wollmann G,von Laer D |
|
Evidence
|
Subsequent sequencing of the P-prot insert (not the whole viral genome) and alignment comparison with the parental plasmid construct revealed one mutation (protease 2: nucleotide G23A; amino acid R8K) in the construct with no effect on the proteolytic control of virus activity (Supplementary Fig. 3d).
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HIV Mutation Detail Information