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Mutation Information

Mutation Site	G321E
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp120

Literature Information

PubMed PMID	21356539
Published Year	2011
Journal	Virology
Title	Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41.
Author	Anastassopoulou CG,Ketas TJ,Depetris RS,Thomas AM,Klasse PJ,Moore JP
Evidence	Thus, the uncloned D101.12 isolate had all four resistance-associated V3 substitutions (K305R, H308P, A316V and G321E), but while the first two changes were fixed, the other two were unstable. And, as noted above, the R14 clone contained only the H308P change.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation