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Mutation Information
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Mutation Site
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G344E |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
Literature Information
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PubMed PMID
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33477685
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Published Year
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2021 |
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Journal
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Viruses |
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Title
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Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction. |
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Author
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Álvarez M,Sapena-Ventura E,Luczkowiak J,Martín-Alonso S,Menéndez-Arias L |
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Evidence
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This engineered mutant, designated as G344E/D345P/ins346F, showed cleavage patterns identical to those obtained with WT HIV-2EHO RT (Figure 8) indicating that introduced changes had a relatively small effect on the location of the susceptible PPT sequence.
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HIV Mutation Detail Information