|
Mutation Information
|
Mutation Site
|
G48V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Relevant Drug
|
saquinavir (SQV) |
Literature Information
|
PubMed PMID
|
25393958
|
|
Published Year
|
2015 |
|
Journal
|
ACS synthetic biology |
|
Title
|
Function-based mutation-resistant synthetic signaling device activated by HIV-1 proteolysis. |
|
Author
|
Majerle A,Gaber R,Benčina M,Jerala R |
|
Evidence
|
The G48V mutant is considered to be the key signature residue mutation of HIV-1 protease in the development of resistance against saquinavir (SAQ) therapy
|
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HIV Mutation Detail Information