|
Mutation Information
|
Mutation Site
|
G5177A |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
Vif |
|
Nucleotide_Mutation
|
S46N |
|
Viral Reference
|
AF324493.2
|
|
Relevant Drug
|
tatinhibitordidehydro-cortistatinA (dCA) |
Literature Information
|
PubMed PMID
|
31266880
|
|
Published Year
|
2019 |
|
Journal
|
mBio |
|
Title
|
Resistance to the Tat Inhibitor Didehydro-Cortistatin A Is Mediated by Heightened Basal HIV-1 Transcription. |
|
Author
|
Mousseau G,Aneja R,Clementz MA,Mediouni S,Lima NS,Haregot A,Kessing CF,Jablonski JA,Thenin-Houssier S,Nagarsheth N,Trautmann L,Valente ST |
|
Evidence
|
One mutation was observed in Vif (Ser46Asn), and the nucleotide change G5177A in the Vpr gene resulted in a truncation (Vpr1-57), which removes the third helix and the flexible C-terminal portion of the protein.
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HIV Mutation Detail Information