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Mutation Information
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Mutation Site
|
G8231A |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
Tax |
|
Viral Reference
|
J02029.1
|
|
Country
|
Brazil |
Literature Information
|
PubMed PMID
|
17067264
|
|
Disease
|
Adult T cell leukemia/lymphoma;
HTLV-1 associated myelopathy/tropical spastic paraparesis
|
|
Published Year
|
2006 |
|
Journal
|
AIDS research and human retroviruses |
|
Title
|
Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region. |
|
Author
|
Kashima S,Alcantara LC,Takayanagui OM,Cunha MA,Castro BG,Pombo-de-Oliveira MS,Zago MA,Covas DT |
|
Evidence
|
Five specific nucleotide substitutions, C7401T, T7914C, C7920T, C7982T, and G8231A, were highly conserved among the Brazilian isolates (79.6%), with a frequency ranging from 81.6% to 100% in the sample group and from 18.4% to 24.1% in the prototypes used, suggesting the existence of a molecular signature.
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HTLV1 Mutation Detail Information