|
Mutation Information
|
Mutation Site
|
H116N |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Nef |
|
Genotype/Subtype
|
B |
|
Viral Reference
|
K03455.1
|
|
Immune Escape
|
Y |
|
Country
|
Boston (USA) |
Literature Information
|
PubMed PMID
|
31693887
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
Cell reports |
|
Title
|
Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity. |
|
Author
|
Jin SW,Alsahafi N,Kuang XT,Swann SA,Toyoda M,Göttlinger H,Walker BD,Ueno T,Finzi A,Brumme ZL,Brockman MA |
|
Evidence
|
We identify 18 Nef polymorphisms associated with differential function, including two CTL escape mutations that contribute to lower SERINC5 downregulation: K94E, driven by HLA-B*08, and H116N, driven by the protective allele HLA-B*57.
|
|
|
HIV Mutation Detail Information