HBV Mutation Detail Information

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Mutation Information

Mutation Site	H238Q
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Country	China

Literature Information

PubMed PMID	31189581
Disease	HBV associated liver disease; Chronic hepatitis B
Published Year	2019
Journal	Journal of clinical microbiology
Title	Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing.
Author	Fu Y,Zeng Y,Chen T,Chen H,Lin N,Lin J,Liu X,Huang E,Wu S,Wu S,Xu S,Wang L,Ou Q
Evidence	Notably, 3 putative NAr mutations (rtL229V, H238Q, and S/C256G) with rates between 20% and 25% tested by NGS in patients 3, 20, and 497, respectively, were not detected by Sanger sequecing, implying the limitation of Sanger sequencing further.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation