HIV Mutation Detail Information

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Mutation Information

Mutation Site	H51Y
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN
Relevant Drug	INSTIs
Country	US

Literature Information

PubMed PMID	31617907
Disease	HIV infection/AIDS
Published Year	2020
Journal	The Journal of antimicrobial chemotherapy
Title	Integrase strand transfer inhibitor (INSTI)-resistance mutations for the surveillance of transmitted HIV-1 drug resistance.
Author	Tzou PL,Rhee SY,Descamps D,Clutter DS,Hare B,Mor O,Grude M,Parkin N,Jordan MR,Bertagnolio S,Schapiro JM,Harrigan PR,Geretti AM,Marcelin AG,Shafer RW,WHO HIVResNet Working Groups.
Evidence	Of the 29 non-polymorphic mutations present in five or more INSTI-treated persons, each was significantly selected by INSTI treatment with corrected P values ≤0.05: H51Y, T66A/I/K, V75I, E92G/Q, Q95K, H114Y, G118R, F121Y, E138A/K/T, G140A/C/S, Y143C/H/R/S, Q146R, S147G, Q148H/K/R, N155H, S230R and R263K (Table 2).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation