EBV Mutation Detail Information

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Mutation Information

Mutation Site	H592A
Mutation Type	Amino acid level
Gene/Protein/Region Type	BRLF1

Literature Information

PubMed PMID	19232420
Published Year	2009
Journal	Virology
Title	Two phenylalanines in the C-terminus of Epstein-Barr virus Rta protein reciprocally modulate its DNA binding and transactivation function.
Author	Chen LW,Raghavan V,Chang PJ,Shedd D,Heston L,Delecluse HJ,Miller G
Evidence	Thus, whether assessed by reporter assays or assays for EBV lytic gene expression, at the level of viral transcripts or viral polypeptide expression, Rta (F600A/F605A), which manifests stronger DNA binding activity than wild-type Rta, was consistently defective as a transactivator.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation