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Mutation Information
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Mutation Site
|
H73E |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
E7 |
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Genotype/Subtype
|
HPV16 |
Literature Information
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PubMed PMID
|
27030265
|
|
Published Year
|
2016 |
|
Journal
|
Journal of virology |
|
Title
|
The Human Papillomavirus 16 E7 Oncoprotein Attenuates AKT Signaling To Promote Internal Ribosome Entry Site-Dependent Translation and Expression of c-MYC. |
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Author
|
Strickland SW,Vande Pol S |
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Evidence
|
Attenuation of phosphorylated AKT (pAKT) by E7 was independent of the Rb degradation function of E7 but could be ablated by a missense mutation in the E7 carboxy terminus, H73E, thereby defining a novel structure-function phenotype for E7.
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HPV Mutation Detail Information