HIV Mutation Detail Information

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Mutation Information

Mutation Site	I135T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	B
Viral Reference	K03455.1
Immune Escape	Y
Country	Canada

Literature Information

PubMed PMID	30048246
Disease	HIV infection/AIDS
Published Year	2018
Journal	AIDS (London, England)
Title	Extensive host immune adaptation in a concentrated North American HIV epidemic.
Author	Brumme ZL,Kinloch NN,Sanche S,Wong A,Martin E,Cobarrubias KD,Sandstrom P,Levett PN,Harrigan PR,Joy JB
Evidence	Strikingly, the Saskatchewan HIV consensus sequence differed from that in the rest of Canada/USA at 9 Pol codons: E35D, P63C and I93L in Protease, and I135T, S162C, P272A, E297A, Q334L, and E399D in reverse transcriptase (Fig. (Fig.1c),1c), a remarkable observation given Pol's relative conservation and the long-term stability of the North American [8] and global (http://www.hiv.lanl.gov/) subtype B Pol consensus sequences.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation