|
Mutation Information
|
Mutation Site
|
I147L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gag |
|
Genotype/Subtype
|
B;C |
|
Viral Reference
|
K03455.1
|
|
Country
|
South Africa |
Literature Information
|
PubMed PMID
|
15067030
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2004 |
|
Journal
|
The Journal of experimental medicine |
|
Title
|
Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection. |
|
Author
|
Draenert R,Le Gall S,Pfafferott KJ,Leslie AJ,Chetty P,Brander C,Holmes EC,Chang SC,Feeney ME,Addo MM,Ruiz L,Ramduth D,Jeena P,Altfeld M,Thomas S,Tang Y,Verrill CL,Dixon C,Prado JG,Kiepiela P,Martinez-Picado J,Walker BD,Goulder PJ |
|
Evidence
|
Similarly, the variation at position Gag 147 involved an isoleucine to leucine polymorphism ("I147L") in 43 out of 61 (70%) of B57+ subjects versus 44 out of 213 (21%) of non-B57 controls (relative risk = 3.4;P < 0.0001).
|
|
|
HIV Mutation Detail Information