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Mutation Information
|
Mutation Site
|
I147L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gag |
|
Genotype/Subtype
|
B |
|
Viral Reference
|
K03455.1
|
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
17311088
|
|
Clinical information
|
Yes
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2007 |
|
Journal
|
PloS one |
|
Title
|
Sequential broadening of CTL responses in early HIV-1 infection is associated with viral escape. |
|
Author
|
Karlsson AC,Iversen AK,Chapman JM,de Oliviera T,Spotts G,McMichael AJ,Davenport MP,Hecht FM,Nixon DF |
|
Evidence
|
In a plasma sequence obtained at estimated week 106 from infection we did not detect any mutations within epitopes in HIV-Nef and HIV-Pol, but the I147L mutation located within the HLA-B57-restricted 147ISPRTLNAW155 (IW9) epitope in HIV-Gag was present, although not in association with the A146P mutation known to alter antigen processing.
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HIV Mutation Detail Information