|
Mutation Information
|
Mutation Site
|
I163V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.N236T+rt.A181V+rt.L180M+rt.I163V |
|
Relevant Drug
|
adefovir (ADV);lamivudine (LAM) |
|
Country
|
Spain |
Literature Information
|
PubMed PMID
|
21911882
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2011 |
|
Journal
|
Annals of hepatology |
|
Title
|
Evolution of hepatitis B virus during long-term therapy in patients with chronic hepatitis B. |
|
Author
|
Arrese E,Basaras M,Blanco S,Ruiz P,Cisterna R |
|
Evidence
|
During ADV and LAM treatment, one patient developed ADV plus LAM resistance mutations (rtI163V+rtL180M+rtA181V+rtN236T), in this case, HBV strains harbouring polymerase mutations did not develop LAM associated rtM204V/I primary mutation.
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HBV Mutation Detail Information