|
Mutation Information
|
Mutation Site
|
I163V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.A186T+rt.L180M+rt.I163V |
|
Relevant Drug
|
entecavir (ETV);lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
30202825
|
|
Disease
|
HBV infection
|
|
Published Year
|
2018 |
|
Journal
|
Hepatology communications |
|
Title
|
Discovery of the Novel Entecavir-Resistant Hepatitis B Virus Reverse Transcriptase A181C Substitution From an Integrated Genotypic Analysis. |
|
Author
|
Rose RE,Hernandez D,Falk PJ,Ericson K,Zhou N,Thiry A,McPhee F |
|
Evidence
|
One patient responded to ETV treatment, and phenotypic analysis of a recombinant clone harboring substitutions rtI163V+rtL180M+rtA186T+rtM204V from this patient showed susceptibility to ETV (4.8‐fold greater than WT) similar to LVDr HBV.
|
|
|
HBV Mutation Detail Information