|
Mutation Information
|
Mutation Site
|
I259V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Genotype/Subtype
|
CRF63_02A1 |
|
Country
|
Russia |
Literature Information
|
PubMed PMID
|
31024744
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
Acta naturae |
|
Title
|
Consensus Integrase of a New HIV-1 Genetic Variant CRF63_02A1. |
|
Author
|
Agapkina YY,Pustovarova MA,Korolev SP,Zyryanova DP,Ivlev VV,Totmenin AV,Gashnikova NM,Gottikh MB |
|
Evidence
|
Preparation of the cDNA encoding IN_CRF and its consecutive cloning allowed us to obtain the pET-15b_IN_CRF* vector, which was then subjected to site-directed mutagenesis to introduce the I32V and I259V substitutions and to obtain the pET-15b_IN_CRF expression vector coding for a consensus IN sequence.
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HIV Mutation Detail Information