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Mutation Information
|
Mutation Site
|
I27K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Genotype/Subtype
|
HPV16 |
|
Country
|
Sweden |
Literature Information
|
PubMed PMID
|
16519914
|
|
Published Year
|
2006 |
|
Journal
|
Virology |
|
Title
|
HPV16 E6 natural variants exhibit different activities in functional assays relevant to the carcinogenic potential of E6. |
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Author
|
Lichtig H,Algrisi M,Botzer LE,Abadi T,Verbitzky Y,Jackman A,Tommasino M,Zehbe I,Sherman L |
|
Evidence
|
The L83V variant (V8) exhibited relatively high binding activity to E6BP when present as sole variation (V8) (6.55%) or in combination with the I27K (V5) (7.8%).
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HPV Mutation Detail Information