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Mutation Information
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Mutation Site
|
I309L |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Gp120 |
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Genotype/Subtype
|
C |
|
Immune Escape
|
Y |
Literature Information
|
PubMed PMID
|
20494390
|
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Published Year
|
2010 |
|
Journal
|
Virology |
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Title
|
Subtype-specific conservation of isoleucine 309 in the envelope V3 domain is linked to immune evasion in subtype C HIV-1 infection. |
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Author
|
Lynch RM,Rong R,Li B,Shen T,Honnen W,Mulenga J,Allen S,Pinter A,Gnanakaran S,Derdeyn CA |
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Evidence
|
For these 11 Envs, I309L did not alter replication in primary CD4 T cells;however, replication in monocyte-derived macrophages was enhanced.
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HIV Mutation Detail Information