HIV Mutation Detail Information

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Mutation Information

Mutation Site	I322A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Viral Reference	K03455.1

Literature Information

PubMed PMID	33785631
Published Year	2021
Journal	mBio
Title	Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State.
Author	Zhang P,Kwon AL,Guzzo C,Liu Q,Schmeisser H,Miao H,Lin Y,Cimbro R,Huang J,Connors M,Schmidt SD,Dolan MA,Armstrong AA,Lusso P
Evidence	The only residues in cluster 1 that are directly involved in an antibody epitope are I322 and I326 for PGT128 (PDB ID: 3TYG), which can explain the drastic loss of PGT128 activity observed against I322A; however, I322A had equally strong effects on virtually all neutralizing reagents tested, regardless of their target region (Fig. 3A), which corroborates a global alteration of the Env spike conformation.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation