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HIV Mutation Detail Information

> I376V Search Result


Mutation Information
Mutation Site I376V
Mutation Type Amino acid level
Gene/Protein/Region Type Gag
Genotype/Subtype B
Literature Information
PubMed PMID 27090171
Published Year 2016
Journal Antimicrobial agents and chemotherapy
Title Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.
Author Nowicka-Sans B,Protack T,Lin Z,Li Z,Zhang S,Sun Y,Samanta H,Terry B,Liu Z,Chen Y,Sin N,Sit SY,Swidorski JJ,Chen J,Venables BL,Healy M,Meanwell NA,Cockett M,Hanumegowda U,Regueiro-Ren A,Krystal M,Dicker IB
Evidence A fourth subtype B virus was insensitive (EC50 of 860 nM) and contained a low-frequency polymorphic triad (V362I/S373L/I376V; <0.5% in the 2012 LANL database).
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation