HIV Mutation Detail Information

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Mutation Information

Mutation Site	I43V
Mutation Type	Amino acid level
Gene/Protein/Region Type	Nef
Genotype/Subtype	B
Viral Reference	K03455.1
Country	Boston (USA)

Literature Information

PubMed PMID	31693887
Disease	HIV infection/AIDS
Published Year	2019
Journal	Cell reports
Title	Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity.
Author	Jin SW,Alsahafi N,Kuang XT,Swann SA,Toyoda M,Göttlinger H,Walker BD,Ueno T,Finzi A,Brumme ZL,Brockman MA
Evidence	Viral Adaptation to T Lymphocytes Contributes to Variability in SERINC5 Downregulation ActivityNotably, three Nef polymorphisms that were associated with a substantial reduction in SERINC5 downregulation function, I43V (-49% activity), K94E (-38%), and H116N (-14%) (Table 1), are viral "escape mutations" selected in CD8+ T cell epitopes restricted by HLA-C03, B08, and B*57, respectively.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation