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Mutation Information
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Mutation Site
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I50V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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PR |
Literature Information
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PubMed PMID
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33085662
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Published Year
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2020 |
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Journal
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PLoS genetics |
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Title
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Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease. |
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Author
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Zhang TH,Dai L,Barton JP,Du Y,Tan Y,Pang W,Chakraborty AK,Lloyd-Smith JO,Sun R |
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Evidence
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These 3 mutants (I50V_T74P, M46I_I54M and L76V_V82F) represent local fitness peaks and the reversal to wild-type is blocked by a fitness valley. We found that the number of accessible reversal paths decreased with the accumulation of RAMs (Fig 4C).
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HIV Mutation Detail Information