|
Mutation Information
|
Mutation Site
|
I54A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Relevant Drug
|
atazanavir (ATV);darunavir (DRV);indinavir (IDV);lopinavir (LPV);nelfinavir (NFV);saquinavir (SQV);tipranavir (TPV) |
Literature Information
|
PubMed PMID
|
28155724
|
|
Published Year
|
2016 |
|
Journal
|
BMC bioinformatics |
|
Title
|
Structural analyses of 2015-updated drug-resistant mutations in HIV-1 protease: an implication of protease inhibitor cross-resistance. |
|
Author
|
Su CT,Ling WL,Lua WH,Haw YX,Gan SK |
|
Evidence
|
While similar protease-destabilizing effect by major mutations was observed in LPV and TPV resistance, the minor mutation G73S (LPV) or I54A (TPV) amplified this effect while compensating for the viral fitness loss.
|
|
|
HIV Mutation Detail Information