|
Mutation Information
|
Mutation Site
|
I54M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
Literature Information
|
PubMed PMID
|
33503916
|
|
Published Year
|
2021 |
|
Journal
|
Molecules (Basel, Switzerland) |
|
Title
|
Structural Impacts of Drug-Resistance Mutations Appearing in HIV-2 Protease. |
|
Author
|
Laville P,Petitjean M,Regad L |
|
Evidence
|
The G48V and I54M mutations increased the hydrophobicity of the pocket that was accompanied with a modification of the pocket size: the G48V mutation led to a reduction of the pocket volume in contrast to the I54M.
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