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HIV Mutation Detail Information

> I559P Search Result


Mutation Information
Mutation Site I559P
Mutation Type Amino acid level
Gene/Protein/Region Type Gp41
Genotype/Subtype A
Literature Information
PubMed PMID 32522853
Published Year 2020
Journal Journal of virology
Title Shedding-Resistant HIV-1 Envelope Glycoproteins Adopt Downstream Conformations That Remain Responsive to Conformation-Preferring Ligands.
Author Lu M,Ma X,Reichard N,Terry DS,Arthos J,Smith AB 3rd,Sodroski JG,Blanchard SC,Mothes W
Evidence Shedding of gp120, known to severely complicate structural studies, can be prevented by using the uncleaved gp160JR-FL precursor with alterations in the protease cleavage site (R508S/R511S) or by introducing a disulfide bridge between gp120 and gp41 designated “SOS” (A501C/T605C).
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation