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Mutation Information
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Mutation Site
|
I84V |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PR |
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Combined Mutation
|
pr.L90M+pr.I84V |
|
Viral Reference
|
K03455.1
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Literature Information
|
PubMed PMID
|
17352531
|
|
Published Year
|
2007 |
|
Journal
|
PLoS computational biology |
|
Title
|
A look inside HIV resistance through retroviral protease interaction maps. |
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Author
|
Kontijevskis A,Prusis P,Petrovska R,Yahorava S,Mutulis F,Mutule I,Komorowski J,Wikberg JE |
|
Evidence
|
This is a position for a distantly acting, commonly appearing drug-resistant mutation, L90M in the HIV-1 protease, which has been observed to increase the cleavage activity of HIV-1 protease for natural substrates mutated in the P1' position.
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HIV Mutation Detail Information