HIV Mutation Detail Information

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Mutation Information

Mutation Site	I84V
Mutation Type	Amino acid level
Gene/Protein/Region Type	PR

Literature Information

PubMed PMID	26012849
Published Year	2015
Journal	Scientific reports
Title	Effects of drug-resistant mutations on the dynamic properties of HIV-1 protease and inhibition by Amprenavir and Darunavir.
Author	Yu Y,Wang J,Shao Q,Shi J,Zhu W
Evidence	Molecular dynamics simulations are performed to investigate the dynamic properties of wild-type HIV-1 protease and its two multi-drug-resistant variants (Flap + (L10I/G48V/I54V/V82A) and Act (V82T/I84V)) as well as their binding with APV and DRV inhibitors.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation