|
Mutation Information
|
Mutation Site
|
K103N |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
efavirenz (EFV) |
Literature Information
|
PubMed PMID
|
30918485
|
|
Published Year
|
2019 |
|
Journal
|
Frontiers in pharmacology |
|
Title
|
The Utility of Efavirenz-based Prophylaxis Against HIV Infection. A Systems Pharmacological Analysis. |
|
Author
|
Duwal S,Seeler D,Dickinson L,Khoo S,von Kleist M |
|
Evidence
|
We predicted that plasma concentrations of 11, 36, 1287 and 1486ng/mL prevent 90% sexual transmissions with wild type and Y181C, K103N and G190S mutants, respectively.
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HIV Mutation Detail Information