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Mutation Information
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Mutation Site
|
K103N |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NNRTIs |
Literature Information
|
PubMed PMID
|
31735575
|
|
Published Year
|
2020 |
|
Journal
|
European journal of medicinal chemistry |
|
Title
|
Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. |
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Author
|
Han S,Sang Y,Wu Y,Tao Y,Pannecouque C,De Clercq E,Zhuang C,Chen FE |
|
Evidence
|
Further optimization on the sulfur led to the sulfinylacetamide-DAPYs exhibiting improved anti-viral activity and a higher selectivity index especially toward the K103N mutant strain.
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HIV Mutation Detail Information