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Mutation Information
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Mutation Site
|
K103N |
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Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
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Combined Mutation
|
rt.K103N+rt.L100I |
|
Relevant Drug
|
nevirapine (NPV);efavirenz (EFV) |
Literature Information
|
PubMed PMID
|
32004936
|
|
Published Year
|
2020 |
|
Journal
|
European journal of medicinal chemistry |
|
Title
|
Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root. |
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Author
|
Xu C,Xin Y,Chen M,Ba M,Guo Q,Zhu C,Guo Y,Shi J |
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Evidence
|
Especially, 10i (EC50 = 0.43 muM) was more active to the L100I/K103N double-mutant strain as compared to both NVP (EC50 = 0.76 muM) and EFV (EC50 = 1.08 muM).
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HIV Mutation Detail Information