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Mutation Information
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Mutation Site
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K103N |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Relevant Drug
|
NNRTIs |
Literature Information
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PubMed PMID
|
33126458
|
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Published Year
|
2020 |
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Journal
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Molecules (Basel, Switzerland) |
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Title
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Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential. |
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Author
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Nahar L,Talukdar AD,Nath D,Nath S,Mehan A,Ismail FMD,Sarker SD |
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Evidence
|
Furthermore, this pyranocoumarin (1) showed activity against HIV with the two most common NNRTI-related mutations, K103N and Y181C, and was found to select for a mutation that does not cause cross-resistance with any other NNRTIs under investigation.
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HIV Mutation Detail Information