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Mutation Information
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Mutation Site
|
K11T |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
E6 |
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Genotype/Subtype
|
HPV16 |
|
Country
|
Sweden |
Literature Information
|
PubMed PMID
|
16519914
|
|
Published Year
|
2006 |
|
Journal
|
Virology |
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Title
|
HPV16 E6 natural variants exhibit different activities in functional assays relevant to the carcinogenic potential of E6. |
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Author
|
Lichtig H,Algrisi M,Botzer LE,Abadi T,Verbitzky Y,Jackman A,Tommasino M,Zehbe I,Sherman L |
|
Evidence
|
Lower activity than the prototype E6 was consistently exhibited by V2 (K11T) in degradation of p53 Pro and in inhibition of p53 Pro and p53 Arg TA.
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HPV Mutation Detail Information