|
Mutation Information
|
Mutation Site
|
K130I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
BCP |
|
Amino acid_Mutation
|
A1762T |
|
Genotype/Subtype
|
D |
|
Country
|
Iran |
Literature Information
|
PubMed PMID
|
16099903
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2005 |
|
Journal
|
The Journal of general virology |
|
Title
|
T1764G1766 core promoter double mutants are restricted to Hepatitis B virus strains with an A1757 and are common in genotype D. |
|
Author
|
Sendi H,Mehrab-Mohseni M,Zali MR,Norder H,Magnius LO |
|
Evidence
|
The T1762A1764 mutant changes two codons in the X protein with the substitutions Met130Ile131, which would decrease the transactivating activity of the X gene product on both pre-core and core transcription (Li et al., 1999).
|
|
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HBV Mutation Detail Information