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Mutation Information
|
Mutation Site
|
K30A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
CA |
|
Viral Reference
|
K03455.1
|
Literature Information
|
PubMed PMID
|
30862755
|
|
Published Year
|
2019 |
|
Journal
|
mBio |
|
Title
|
Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket. |
|
Author
|
Craveur P,Gres AT,Kirby KA,Liu D,Hammond JA,Deng Y,Forli S,Goodsell DS,Williamson JR,Sarafianos SG,Olson AJ |
|
Evidence
|
To test their effect on the formation of the HIV particle before maturation, E28A, K30A, and E28A/K30A mutations were introduced into a plasmid construct containing the HIV-1 Gag polyprotein (see Materials and Methods).
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HIV Mutation Detail Information