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Mutation Information
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Mutation Site
|
K415R |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Gag |
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Genotype/Subtype
|
C |
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Relevant Drug
|
PIs |
Literature Information
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PubMed PMID
|
25253273
|
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Disease
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HIV infection/AIDS
|
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Published Year
|
2014 |
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Journal
|
Retrovirology |
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Title
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HIV-1 Gag C-terminal amino acid substitutions emerging under selective pressure of protease inhibitors in patient populations infected with different HIV-1 subtypes. |
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Author
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Li G,Verheyen J,Theys K,Piampongsant S,Van Laethem K,Vandamme AM |
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Evidence
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A significant association was found for 13 Gag substitutions, including A431V in both subtype B and CRF01_AE. K415R in subtype C and S451G in subtype B were newly identified. Most PI-associated Gag substitutions are located in the flexible C-terminal domain, revealing the key role this region plays in PI resistance.
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HIV Mutation Detail Information